Role of plasmacytoid dendritic cells (pDCs) in the endogenous production of type I interferons during acute HCV

In this study, we investigated whether plasmacytoid dendritic cells (pDCs) were activated as a result of HCV infection. We demonstrated that even during acute infection, circulating pDCs maintained a similar precursor frequency and resting phenotype as compared to healthy individuals. Moreover, stimulation with a TLR9 agonist resulted in an intact inflammatory response.


Main conclusion of this study: these data support the growing consensus that pDCs are not directly activated by HCV and therefore are viable targets for immunotherapy throughout HCV infection.


Read more: Mansour et al., J Infect Dis, 2010


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Introduction of Sofosbuvir in Egypt

In July 2014, Gilead and the Egyptian government signed an agreement for a treatment expansion of Sovaldi® (Sofosbuvir). Read more

Scientific Advisory Board Meeting

The Scientific Advisory Board Meeting was held in Paris February 15-16, 2013.

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fp7_01fp7_02 This project is funded
by the European Union